Endocrine Abstracts

Background: Hormone therapy is an important part of transition for many gender nonconforming people and implant treatment is an alternative route of oestrogen administration. We assessed the efficacy of oestrogen implant in transwomen for hormone replacement therapy.Methods: 83 transgender women had 100 mg estradiol implant inserted subcutaneously in the anterior abdominal wall. All subjects graded their energy, drive and libido from a scale of 0 to 10 p...

Introduction: Hypokalemic periodic paralysis (HPP), is a rare neuromuscular disorder caused by dysfunction of the ion channels in red muscle cells which is characterized by painless episodes of muscle weakness generally after strenuous exertion or a high-carbohydrate meal. However, some HPP patients secondary to thyrotoxicosis are also described.Case: A 41-year-old Caucasian man, without any chronic disease, presented to our emergency department with gen...

Background & Aim: Adrenocortical carcinoma (ACC) is an extremely rare malignancy usually with poor outcomes, although the prognosis varies greatly depending on the initial tumor stage. Here we present clinical and outcome diversity of the patients in a single center.Methods: We retrospectively analyzed 16 patients with ACC diagnosed between 2000 and 2022. Demographical findings, hormonal status, radiological findings, ENSAT stage, weiss score and Ki6...

Background: Insulinoma is a rare tumour representing 1–2% of all pancreatic neoplasms and it is malignant in only 10% of cases. Locoregional invasion or metastases define malignancy, whereas dimension (> 2 cm), CK19 status, tumor staging and grading (Ki67 > 2%), and age of onset (> 50 years) can be considered elements of suspect.Case presentation: We report a case of malignant insulinoma in a 80 year old woman presenting symptoms c...

Introduction: Insulinoma is the most common functional pancreatic neuroendocrine tumor (PanNET), accounting for more than 50% of all cases. Diagnosis of insulinomas may be challenging. In this study, we aim to discuss the clinicopathological features and long-term follow-up results of insulinoma cases followed up in our clinic.Material and Methods: It is a descriptive and retrospective study of 13 insulinoma cases diagnosed over 10 years. All data of the...

Introduction: Thyroid papillary cancer is a solid organ malignancy that can be cured mostly by surgical and radioactive iodine(RAI) therapy. Metastatic disease state and radioactive iodine resistance have led to new treatment searches. In recent years, sorafenib, a tyrosine kinase inhibitor, has been used as a first-line treatment in thyroid papillary cancers that cannot be cured by surgery or radioactive iodine treatment. In addition, the use of thermal ablation and transarte...

Objective: Various effects of glucocorticoids occur in brown adipose tissue depending on their duration of action. As a result of exposure to glucocorticoids, thermogenesis and oxygen use in brown fat tissue are reduced in animal studies. In this study, we aimed to compare the levels of UCP1 (uncoupling protein 1), Irisin, BMP 7 (bone morpogenic protein), PRDM16, which are brown addipose tissue markers, between patients with Cushing’s disease and healthy controls<p c...

IntroductionThe most common causes of pseudo Cushing syndrome are alcoholism, chronic kidney disease, neuropsychiatric diseases, pregnancy, uncontrolled diabetes, and drugs. We present a patient who was operated on suspected Cushing syndrome based on abnormal results in overnight dexamethasone suppression tests.Case presentationA 49-year-old female patient was referred to our clinic for reoperation due to per...

Introduction: Neuroendocrine tumors (NETs) are rare tumors harboring overexpression of somatostatin receptors (SSTRs) on their cell membrane. Gallium 68-tetraazacyclododecane tetraacetic acid-octreotate (68Ga-DOTATATE) positron emission tomography/computed tomography (PET/CT) is an important imaging modality in diagnosis and staging of NETs. Because some organs such as spleen, adrenal glands and liver physiologically express SSTR, it might be challenging to distinguish some pa...

IntroductionVarious direct and indirect mechanisms by which glucocorticoid (GC) excess and elevated adrenocorticotropic hormone (ACTH) levels impairs bone metabolism have been described. In the literature, there are different factors described which affect the early outcome of pituitary surgery in patients with CD including preoperative ACTH levels and the clinical severity of the disease. Combining these data, we conducted a retrospective study to inves...